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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

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Related Experiment Video

Updated: Jul 4, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Bone and fat connection in aging bone.

Gustavo Duque1

  • 1Nepean Clinical School, University of Sydney, Penrith, New South Wales, Australia. gduque@med.usyd.edu.au

Current Opinion in Rheumatology
|June 6, 2008
PubMed
Summary
This summary is machine-generated.

Age-related bone loss involves mesenchymal stem cells differentiating into fat cells. Bone marrow fat accumulation negatively impacts bone health but may offer new diagnostic and therapeutic strategies for osteoporosis.

More Related Videos

Analysis and Imaging of Osteocytes
10:19

Analysis and Imaging of Osteocytes

Published on: November 29, 2024

Related Experiment Videos

Last Updated: Jul 4, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Analysis and Imaging of Osteocytes
10:19

Analysis and Imaging of Osteocytes

Published on: November 29, 2024

Area of Science:

  • * Endocrinology and Metabolism
  • * Bone Biology and Osteoporosis Research

Background:

  • * The interplay between bone and fat is crucial in age-related bone loss.
  • * Mesenchymal stem cells (MSCs) play a key role, with their differentiation skewed towards adipocytes (fat cells) during aging.

Purpose of the Study:

  • * To review age-induced mechanisms driving MSCs differentiation into adipocytes.
  • * To explore the role of bone marrow fat as a diagnostic and therapeutic target for osteoporosis.

Main Methods:

  • * Review of current literature on the fat-bone connection in aging.
  • * Analysis of mechanisms regulating MSCs fate.
  • * Evaluation of bone marrow fat quantification and therapeutic potential.

Main Results:

  • * Two connections exist: systemic (obesity-related, high bone mass) and local (within bone marrow).
  • * Increased bone marrow fat inhibits osteoblast function and promotes osteoclast activity via paracrine signaling (fatty acids, adipokines).
  • * Bone marrow fat can be noninvasively quantified and potentially used therapeutically due to its transdifferentiation capacity.

Conclusions:

  • * Bone marrow fat accumulation exemplifies lipotoxicity within the bone microenvironment.
  • * Bone marrow fat represents a promising novel biomarker and therapeutic avenue for osteoporosis in aging populations.