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Prolonged survival with continuous infusion topotecan: a report of 2 cases
Kathryn J Klopfenstein1, Suzanne Scott, David E Schuller
1Department of Pediatrics, East Tennesse State University, Johnson City, TN 37601, USA. klopfens@etsu.edu
Abstract:
Two patients with solid tumors were treated with 21-day continuous infusion topotecan as palliation therapy. Case 1: A 10-year-old girl was diagnosed with progressive, metastatic hepatocellular carcinoma. Twenty-one-day continuous infusion topotecan was started and she has had a partial response. Case 2: A 17-year-old girl developed a malignant fibrous histiocytoma as a second malignant neoplasm. After partial resection and failure of multiagent chemotherapy, she started continuous infusion topotecan and was disease-free for 58 months when she died of pneumonia. These cases suggest that topotecan given as 21-day continuous infusion is efficacious for palliation care.
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