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An attempted reversal of cocaine-induced analgesia by dexamethasone
A Pertovaara1, T Kauppila, E Mecke
1Department of Physiology, University of Helsinki, Finland.
Pharmacology & Toxicology
|February 1, 1991
Abstract:
Analgesia produced by systemic cocaine (20 mg/kg intraperitoneally) was not attenuated by dexamethasone (0.25-2.5 mg/kg) in the formalin or tail pinch test in rats. The result suggests that the activation of the corticotropin releasing factor-adrenocorticotropin/beta-endorphin axis does not explain cocaine-induced analgesia.