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Updated: Aug 28, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
[Developmental disorders of the lungs and tuberculosis]
Abstract:
Surgical biopsy of 536 pulmonary tuberculosis patients was analysed. It was found that in 90% of them tuberculosis developed in the malformed segment of lung tissue. Among the defects, basic matter was composed of small hypoplasia zones (2-3 cm) which were detected only morphologically. In 89% of the cases, zones of hypoplasia and cysts were located in the 1st and 2nd lung segments, which formed in the first postnatal months. In all cases tuberculosis affected the malformed bronchus, which was probably the primary site of tuberculosis process dissemination.
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