[Synthesis and structure elucidation of single and multiple thionated barbituric acid derivatives]

Merbarone [5-(N-phenylcarboxamido)-2-thiobarbituric acid] was developed to clinical trial stage on the basis of its curetive activity against P388 and L1210 leukemias. In the present paper the synthesis of new thioanalogues of pento- and hexobarbital is described. All new compounds were characterized by their spectroscopic data.