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Related Concept Videos

Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...

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Related Experiment Video

Updated: Jul 4, 2026

Extracellular Vesicle Tissue Factor Activity Assay
03:53

Extracellular Vesicle Tissue Factor Activity Assay

Published on: December 29, 2023

Tissue factor; from Morawitz to microparticles.

Nigel S Key1, Jian-Guo Geng, Ronald R Bach

  • 1Division of Hematology/Oncology, University of North Carolina at Chapel Hill, NC 27599, USA. Nigel_key@med.unc.edu

Transactions of the American Clinical and Climatological Association
|June 6, 2008
PubMed
Summary
This summary is machine-generated.

Tissue factor initiates blood coagulation. While its role in health and disease is debated, research suggests it may be a viable therapeutic target for various human conditions.

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Last Updated: Jul 4, 2026

Extracellular Vesicle Tissue Factor Activity Assay
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Published on: December 29, 2023

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Area of Science:

  • Biochemistry
  • Hematology
  • Physiology

Background:

  • Tissue factor is the primary activator of blood coagulation in vivo.
  • Extravascular tissue factor has been known for over a century.
  • Its role in the intravascular compartment and in hemostatic/thrombotic disorders remains under investigation.

Purpose of the Study:

  • To review the historical and current understanding of tissue factor's role in coagulation.
  • To explore the potential of tissue factor as a therapeutic target.

Main Methods:

  • Literature review of historical and contemporary research on tissue factor.
  • Analysis of proposed roles in coagulation and disease states.

Main Results:

  • Tissue factor's function as a cell-based enzymatic cofactor in coagulation was proposed in 1905.
  • Low levels of circulating tissue factor have been detected intravascularly.
  • Its precise role in hemostasis and thrombosis is still debated.

Conclusions:

  • Despite ongoing debate, tissue factor's significance in coagulation is established.
  • Emerging research indicates tissue factor as a potential therapeutic target for human diseases.