A Role for the PPARgamma in Cancer Therapy

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Moray J Campbell1, Carsten Carlberg, H Phillip Koeffler

  • 1Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

PPAR Research
|June 6, 2008
PubMed

Insights

Peroxisome proliferator-activated receptor gamma (PPARgamma) shows promise as a cancer therapeutic target for differentiation therapy. Recent research clarifies its role in chemoprevention and chemotherapy, enhancing its clinical potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Peroxisome proliferator-activated receptor gamma (PPARgamma) was identified in 1997 as a cancer therapeutic target regulating cancer cell differentiation.
  • Initial enthusiasm for PPARgamma ligands in differentiation therapy was tempered by contradictory findings in preclinical models and clinical trials.
  • Recent advances have led to a resurgence in targeting PPARgamma for cancer chemoprevention and chemotherapy.

Purpose of the Study:

  • To review the evolving understanding of PPARgamma's role in cancer therapy.
  • To highlight the recent renaissance in targeting PPARgamma for chemoprevention and chemotherapy.
  • To discuss the translational insights gained from improved understanding of PPARgamma biology and preclinical models.

Main Methods:

  • Review of published literature on PPARgamma in cancer therapy.
  • Analysis of PPARgamma biology, including protein interactions and signaling pathways.
  • Evaluation of findings from murine cancer models and clinical trials.

Main Results:

  • PPARgamma's complex role in cancer has been clarified through a deeper understanding of its biology and transcriptional modulation.
  • Improved translational insights from in vivo murine cancer models have emerged.
  • The potential for PPARgamma targeting in both chemoprevention and chemotherapy is increasingly recognized.

Conclusions:

  • Targeting PPARgamma represents a promising strategy for cancer chemoprevention and chemotherapy.
  • Further research is needed to precisely define PPARgamma's actions and optimize its clinical application.
  • Understanding the mechanisms limiting PPARgamma's anticancer effectiveness is crucial for successful clinical exploitation.

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