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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Related Experiment Video

Updated: Jul 4, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

[Autologous osteochondral transplants].

R Schnettler1, U Horas, C Meyer

  • 1Klinik und Poliklinik für Unfallchirurgie, Universitätsklinikum Giessen und Marburg, Standort Giessen, Rudolf-Buchheim-Strasse 7, 35385, Giessen. reinhard.schnettler@chiru.med.uni-giessen.de

Der Orthopade
|June 6, 2008
PubMed
Summary
This summary is machine-generated.

Osteochondral transplantation restores knee cartilage and bone defects using grafts from the patellofemoral joint. This technique offers long-term hyaline cartilage repair for specific knee injuries.

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Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
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Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
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Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

Related Experiment Videos

Last Updated: Jul 4, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

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Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
08:58

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

Area of Science:

  • Orthopedic Surgery
  • Regenerative Medicine
  • Biomedical Engineering

Context:

  • Osteochondral defects affect cartilage and subchondral bone, impacting joint function.
  • Current treatments aim to restore native tissue and joint mechanics.
  • Osteochondral transplantation utilizes autologous grafts for defect repair.

Purpose:

  • To describe the technique, indications, and outcomes of osteochondral transplantation.
  • To evaluate the efficacy of press-fit implantation for osteochondral defects.
  • To highlight the importance of donor site considerations and limitations.

Summary:

  • Osteochondral transplantation involves harvesting and implanting osteochondral cylinders into knee joint defects.
  • Ideal indications include isolated grade III-IV cartilage lesions in load-bearing areas and specific patellar/talus defects (1-3 cm²).
  • This technique is the only current surgical method for long-term hyaline cartilage defect coverage, though donor site morbidity requires careful management.

Impact:

  • Provides a viable surgical option for articular cartilage and subchondral bone restoration.
  • Enables long-term defect coverage with hyaline cartilage, potentially delaying or avoiding joint replacement.
  • Emphasizes the need for precise patient selection and technique modification to minimize donor site morbidity.