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19F-MRI of stomach and intestine using 50% FTPA emulsion under 2 T MRI system
M Shimizu1, T Kobayashi, H Mishima
1Second Department of Surgery, Osaka University School of Medicine, Japan.
Abstract:
1H-MRI is of clinical value in many lesions, but imaging of gastrointestinal lesions is still difficult by 1H-MRI. To overcome this weak point of 1H-MRI, rabbit stomachs were examined by 19F-MRI using 50% FTPA emulsion. We also examined the stability of 50% FTPA emulsion in the stomach and its absorption from the gastrointestinal tract. We found that 50% FTPA emulsion was very stable at pH 1.5, and only a very small amount was absorbed. A rabbit (weighing 2 kg) was anesthetized, and 100 ml of 50% FTPA emulsion was infused into the stomach by catheter. 19F-MRI was performed in this rabbit using a 2 T superconducting MRI system designed for human use, and clear pictures of the stomach were obtained. From our results we conclude that 19F-MRI of the stomach using 50% FTPA emulsion is of practical value.
Insights
Fluorine-19 MRI (19F-MRI) with FTPA emulsion offers a novel solution for imaging gastrointestinal lesions, overcoming limitations of traditional 1H-MRI. This technique provides clear stomach imaging in rabbits, demonstrating practical clinical value.
Area of Science:
- Medical Imaging
- Gastroenterology
- Biomedical Engineering
Background:
- Proton MRI (1H-MRI) faces challenges in visualizing gastrointestinal lesions.
- Developing advanced imaging techniques is crucial for improved diagnosis and treatment.
Purpose of the Study:
- To evaluate the efficacy of Fluorine-19 MRI (19F-MRI) for imaging rabbit stomachs.
- To assess the stability and gastrointestinal absorption of 50% FTPA emulsion as a contrast agent.
Main Methods:
- Rabbit stomachs were imaged using 19F-MRI with 50% FTPA emulsion.
- Stability of the emulsion at pH 1.5 and its absorption were investigated.
- A 2 T superconducting MRI system was utilized for imaging.
Main Results:
- 19F-MRI produced clear images of the rabbit stomach.
- 50% FTPA emulsion demonstrated high stability in acidic conditions (pH 1.5).
- Minimal absorption of the emulsion from the gastrointestinal tract was observed.
Conclusions:
- 19F-MRI using 50% FTPA emulsion is a viable and practical method for stomach imaging.
- This technique holds promise for overcoming the limitations of 1H-MRI in gastrointestinal applications.
- Further research may lead to improved diagnostic capabilities for gastrointestinal conditions.