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Related Experiment Videos

[Hypoglycemia induced by cibenzoline in the elderly].

C Houdent1, C Noblet, C Vandoren

  • 1Clinique Médicale B, CHRU de ROUEN, Hôpital de Bois-Guillaume.

La Revue De Medecine Interne
|March 1, 1991
PubMed
Summary

Class IA antiarrhythmic agents can cause hypoglycemia. This report details a case of cibenzoline-induced hypoglycemia in an elderly patient with renal impairment and malnutrition, highlighting potential contributing factors and the uncertainty of its mechanism.

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Area of Science:

  • Cardiology
  • Pharmacology
  • Endocrinology

Background:

  • Class IA antiarrhythmic agents are known to induce hypoglycemia.
  • Cibenzoline is a class IA antiarrhythmic agent.

Observation:

  • An 84-year-old patient experienced hypoglycemia attributed to cibenzoline therapy.
  • Facilitating factors included advanced age, renal impairment, and malnutrition.
  • Blood insulin levels were within normal limits (absolute and relative).

Findings:

  • Therapeutic overdosage, considering age and renal function, was identified in 20 of 24 reported cases.
  • The precise mechanism of cibenzoline-induced hypoglycemia remains uncertain.
  • Absolute or relative hyperinsulinism was detected in only 5 of 14 controlled cases.

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Implications:

  • This case underscores the importance of cautious dosing of cibenzoline in elderly patients with compromised renal function.
  • Further research is needed to elucidate the exact mechanism of drug-induced hypoglycemia.
  • Pharmacovigilance systems play a crucial role in identifying and reporting adverse drug events.