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Analysis of initial burst in PLGA microparticles
1South Carolina College of Pharmacy, Department of Pharmaceutical and Biomedical Sciences, Columbia, SC 29205, USA. allison@cop.sc.edu
Expert Opinion on Drug Delivery
|June 6, 2008
Summary
Controlling initial burst release from poly(lactide-co-glycolide) (PLGA) microparticles is crucial for safe and effective drug delivery. Strategies focus on improving drug-polymer miscibility and optimizing processing methods to reduce premature drug expulsion.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Polymer Chemistry
Background:
- Poly(lactide-co-glycolide) (PLGA) microparticles are widely used for sustained drug delivery.
- Excessive initial burst release can lead to drug toxicity and inconsistent dosing.
- Poor drug-polymer miscibility is a key challenge in PLGA microparticle formulations.
Purpose of the Study:
- To review recent advances in understanding burst release mechanisms from PLGA microparticles.
- To summarize strategies for controlling burst release in PLGA formulations.
Main Methods:
- Literature review focusing on publications since 2004.
- Analysis of formulation and processing strategies to mitigate burst release.
Main Results:
- Strategies involve enhancing drug-polymer miscibility (e.g., altering drug salt form).
- Processing modifications, such as controlled solvent removal, can prevent drug-polymer separation.
- The primary goal is to minimize burst release for improved drug retention.
Conclusions:
- Understanding burst release mechanisms is key to developing effective control strategies.
- Formulation and processing adjustments offer viable methods to reduce premature drug release from PLGA microparticles.
- Optimizing these strategies ensures better drug retention for sustained therapeutic effects.
