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Updated: Jul 4, 2026

Differential Labeling of Cell-surface and Internalized Proteins after Antibody Feeding of Live Cultured Neurons
Published on: February 12, 2014
Secretory outposts for the local processing of membrane cargo in neuronal dendrites
Cyril Hanus1, Michael D Ehlers
1Department of Neurobiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
Abstract:
The large size and geometric complexity of neuronal dendrites necessitate specialized mechanisms to both deliver postsynaptic cargo over extended distances and regulate dendritic composition on a submicron scale. Despite the fundamental importance of membrane trafficking in dendrite growth, synapse formation and plasticity, the organelles and cellular rules governing postsynaptic trafficking are only now emerging. Here we review what is currently known about dendritic secretory organelles and their role in the development, maintenance and plasticity of postsynaptic compartments.
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