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Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jul 4, 2026

Models of Bone Metastasis

Models of Bone Metastasis

Published on: September 4, 2012

TMJ metastasis: a unusual case report.

Roberto Boniello¹, Giulio Gasparini, Giuseppe D'Amato

¹Department of Maxillo Facial Surgery, Catholic University Medical School, Rome, Italy. dr.boniello@yahoo.it

Head & Face Medicine

|June 6, 2008

Summary

Metastases from lung cancer to the temporomandibular joint (TMJ) are rare. In this case, TMJ dislocation was the initial symptom of lung cancer, with CT scans revealing it as the sole bone metastasis.

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Last Updated: Jul 4, 2026

Models of Bone Metastasis

Models of Bone Metastasis

Published on: September 4, 2012

Area of Science:

Oncology
Radiology
Otorhinolaryngology

Background:

Lung cancer is a leading cause of cancer-related deaths globally.
Metastasis to the temporomandibular joint (TMJ) from lung cancer is exceptionally rare.

Observation:

A patient presented with a non-reducible temporomandibular joint (TMJ) dislocation.
This TMJ dislocation was the first clinical sign identified, preceding other diagnoses.

Findings:

Computed tomography (CT) staging confirmed the TMJ lesion as a metastasis from a primary lung tumor.
The CT scan indicated that this condylar metastasis was the only detected bone metastasis in the entire body.

Implications:

This case highlights the importance of considering rare metastatic sites in cancer diagnosis.
TMJ symptoms can be an unusual initial presentation of advanced lung cancer.
Early detection of bone metastasis through advanced imaging like CT is crucial for staging and treatment planning.