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Related Concept Videos

Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Related Experiment Video

Updated: Jul 4, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

[Granular cell tumor].

L Ayadi1, A Khabir, I Fakhfakh

  • 1Laboratoire d'anatomie et de cytologie pathologiques, CHU Habib-Bourguiba, Sfax, Tunisie. ayadilobna@yahoo.fr

Revue De Stomatologie Et De Chirurgie Maxillo-Faciale
|June 6, 2008
PubMed
Summary
This summary is machine-generated.

Granular cell tumors (GCTs), also known as Abrikossoff tumors, are rare neurogenic neoplasms. While typically benign and treatable with surgery, accurate diagnosis is crucial to distinguish them from malignant growths.

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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Related Experiment Videos

Last Updated: Jul 4, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Area of Science:

  • Oncology
  • Pathology
  • Neurosurgery

Context:

  • Granular cell tumors (GCTs), or Abrikossoff tumors, are rare neurogenic neoplasms.
  • Predominantly located in the cervicofacial region, GCTs typically affect individuals aged 40-60, with a higher incidence in females.
  • These tumors represent a small fraction of all neoplasms, occurring in 0.019% to 0.03% of cases.

Purpose:

  • To review the characteristics of granular cell tumors (GCTs).
  • To highlight diagnostic challenges, particularly differentiating benign GCTs from malignant neoplasms.
  • To emphasize the importance of neurogenic markers and Periodic Acid Schiff (PAS) staining in diagnosis.

Summary:

  • GCTs are generally benign neurogenic tumors with a favorable prognosis following surgical excision.
  • Histological examination is typically specific, but misdiagnosis as malignancy can occur with insufficient biopsy samples.
  • Malignant GCTs are exceptionally rare, characterized by recurrence and metastasis, necessitating wide surgical excision.

Impact:

  • Accurate diagnosis of GCTs is essential for appropriate patient management and treatment planning.
  • Understanding the specific histological and immunohistochemical features aids in distinguishing GCTs from other tumors.
  • Early and correct diagnosis ensures favorable outcomes for the vast majority of patients with benign GCTs.