Increased orexin levels in the cerebrospinal fluid the first year after a suicide attempt
Lena Brundin1, Maria Björkqvist, Lil Träskman-Bendz
1Division of Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden. Lena.Brundin@med.lu.se
Background:
The orexins (hypocretins) and cocaine and amphetamine regulated transcript (CART) are hypothalamic peptides involved in the regulation of sleep and appetite. We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms.
Methods:
Ten patients took part in lumbar punctures and psychiatric evaluations in conjunction to a suicide attempt and after 6 and 12 months. We measured CSF-orexin and CART using radioimmunoassays.
Results:
Mean CSF-orexin was significantly higher at the first and second follow-up than at the suicide attempt. In contrast, mean CSF-CART did not differ over time. Total SUAS scores, as well as ratings of CPRS item 66 (global illness) were significantly lower at follow-up. At one year, there was a significant negative correlation between the change in CSF-orexin and the change in total SUAS score.
Limitations:
The number of patients who participated was relatively small.
Conclusions:
Our results support the hypothesis that orexin is involved in psychiatric symptomatology.
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