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Updated: Jul 4, 2026

Measuring RAN Peptide Toxicity in C. elegans
Published on: April 30, 2020
Susceptibility to chronic inflammatory demyelinating polyradiculoneuropathy is associated to polymorphic GA repeat in
Francesca Notturno1, Marta Pace, Maria V De Angelis
1Department of Human Motor Sciences, Institute of Aging , Foundation University G. d'Annunzio, Chieti-Pescara, Italy.
Abstract:
The SH2D2A gene encodes a T-cell-specific adapter protein involved in the negative control of T-cell activation. The genotype GA13-16 homozygote of the SH2D2A gene promoter has been associated with the susceptibility to develop multiple sclerosis. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated neuropathy sharing several pathogenetic mechanisms with multiple sclerosis. We genotyped the SH2D2A promoter region in 105 controls and 48 patients with CIDP. We found a significant association between CIDP and the genotype GA13-16 homozygote (OR 3.167; p 0.013). We hypothesize that this genotype is associated with the susceptibility to develop CIDP and may be implicated in the persistence of the disease.
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