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[Studies on separation, appraisal and the biological activity of 5-HMF in Cornus officinalis]
Xia Ding1, Ming-Yan Wang, Zong-Liang Yu
1Department of Chemistry, Nanjing Agricultural University, Nanjing 210095, China. jsnnnxd405@yahoo.com.cn
Objective:
To develop the mechanism of improving protection function of prepared Cornus officinalis for liver and kidney and the biological activity of 5-hydroxymethylfurfural (5-HMF).
Method:
Pharmacological and chemical studies were used to choose active part. A compound from active part was separated and appraised. To investigate his biological functions, pharmacological experiment was actualized.
Result:
A component was separated and identified. His is 5-HMF. 5-HMF can protect human vein epidermal cell against H2O2 and glucose and inprove acute liver injury in mice.
Conclusion:
5-HMF is the active component in prepared Cornus officinalis and substance basis for protecting liver and kidney.
