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Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
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Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

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Amplifying small amounts of tumor DNA allows detection of DNA copy number abberations with array-CGH

Lars Prestegarden1, Anjan Misra, Marcus L Ware

  • 1NorLux Neuro Oncology, Department of Biomedicine, University of Bergen, Bergen, Norway. lars.prestegarden@student.uib.no

Biotechniques
|June 7, 2008
PubMed

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DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...