Related Experiment Video
Updated: Jul 4, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
The possible role of reticulocytes in sickle cell disease associated thromboembolism
1Haematology Department, Royal, Liverpool University Hospital, UK. jeckothachil@yahoo.co.uk
Abstract:
Sickle cell disease (SCD) is associated with an increased incidence of deep vein thrombosis and pulmonary embolism which contributes to the morbidity and mortality associated with it. The predisposition to thrombosis has been attributed to the different blood components including platelets, the coagulation system and recently damaged red cells. This article discusses the possible role of reticulocytes in promoting thrombus formation in individuals with SCD and suggests a similar pathogenetic mechanism in thromboembolism associated with other hemolytic states.
Related Concept Videos
Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Multiple Allele Traits
Erythropoiesis
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Rh Blood Group
Structure and Function of Platelets
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
