Related Experiment Video
Updated: Jul 4, 2026

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs)
Published on: May 12, 2017
Stem cells in the heart: what's the buzz all about? Part 2: Arrhythmic risks and clinical studies
Rachel Ruckdeschel Smith1, Lucio Barile, Elisa Messina
1Capricor Inc., Los Angeles, California, USA.
Abstract:
New approaches for cardiac repair have been enabled by the discovery that the heart contains its own reservoir of stem cells. In Part 1 of this review, we discussed various cardiac stem cell populations, reviewed our own work on cardiosphere-derived cells from human hearts, and outlined large animal preclinical models testing the regenerative potential of cardiac stem cells. Here we continue with a discussion on other adult stem cell sources with clinical potential. We summarize the critical safety issues associated with stem cell therapy and present the possible proarrhythmic and antiarrhythmic effects of stem cell transplantation. We discuss the outcomes of clinical stem cell trials and identify the technical, ethical, and practical issues facing the clinical application of cardiac stem cells.
Related Concept Videos
Mechanism of Cardiac Arrhythmias
Dysrhythmias V: Evaluating Dysrhythmias
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Dysrhythmias VI: Management of Dysrhythmias
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

