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Updated: Jul 4, 2026

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
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Carp vitellogenin detection by an optical waveguide lightmode spectroscopy biosensor.

Namsoo Kim1, Dong-Kyung Kim, Yong-Jin Cho

  • 1Food Nano-Biotechnology Research Center, Korea Food Research Institute, Songnam-Si, Kyonggi-Do, Republic of Korea.

Biosensors & Bioelectronics
|June 7, 2008
PubMed
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A novel label-free immunosensor detects carp vitellogenin, a key biomarker for endocrine disruptors in fish. This technology enables sensitive, on-site monitoring of potential contamination in edible fish populations.

Area of Science:

  • Environmental Science
  • Analytical Chemistry
  • Biotechnology

Background:

  • Endocrine disruptors pose risks to aquatic ecosystems and human health.
  • Vitellogenin is a crucial biomarker for exposure to estrogenic compounds in fish.
  • On-site monitoring of fish health is essential for managing aquaculture and environmental safety.

Purpose of the Study:

  • To develop and validate a sensitive, label-free immunosensor for carp vitellogenin detection.
  • To assess the sensor's specificity, limit of detection, and reusability.
  • To demonstrate the sensor's applicability for monitoring endocrine disruptor exposure in real-world samples.

Main Methods:

  • Optical waveguide lightmode spectroscopy (OWLS) based immunosensor.
  • Direct-binding assay utilizing specific antibody immobilization.

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Last Updated: Jul 4, 2026

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  • Analysis of purified carp vitellogenin and spiked carp serum samples.
  • Detection of vitellogenin in carp serum samples after 17beta-estradiol induction.

    • Main Results:

    • The immunosensor demonstrated specific binding to carp vitellogenin.
    • A linear relationship was observed between carp vitellogenin concentration (0.00675–67.5 nM) and sensor response.
    • The limit of detection was determined to be 0.00675 nM.
    • The sensor showed good reusability with a coefficient of variability of 6.02% over nine measurements.
    • Biomarker induction was detectable in carp serum samples diluted up to 2000-fold.

    Conclusions:

    • The developed label-free immunosensor offers a sensitive and specific method for carp vitellogenin detection.
    • This technology has strong potential for on-site monitoring of endocrine disruptor contamination in edible fish.
    • The sensor provides a valuable tool for environmental risk assessment and aquaculture management.