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Systemic neonatal candidiasis.

M Reid1, N Rollins, H Halliday

  • 1Neonatal Intensive Care Unit, Royal Maternity Hospital, Belfast.

The Ulster Medical Journal
|April 1, 1991
PubMed
Summary
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Systemic neonatal candidiasis affects critically ill, low birthweight infants. Early diagnosis and treatment with amphotericin B and 5-flucytosine significantly reduce mortality in neonatal intensive care units.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Pediatric Intensive Care

Background:

  • Systemic neonatal candidiasis is a serious fungal infection in premature infants.
  • Low birthweight infants (<1.5 kg) are particularly vulnerable due to immature immune systems and frequent complications like bacterial sepsis.

Purpose of the Study:

  • To report the incidence and outcomes of systemic neonatal candidiasis.
  • To evaluate the efficacy and safety of antifungal treatment in a neonatal intensive care unit (NICU) setting.

Main Methods:

  • Retrospective analysis of 45 cases of systemic neonatal candidiasis over a 9-year period.
  • Focus on infants weighing less than 1.5 kg with severe illness and complications.

Main Results:

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  • Forty-two of 45 affected infants weighed less than 1.5 kg and had severe preceding illnesses.
  • Treatment with amphotericin B and 5-flucytosine resulted in low mortality (4 deaths out of 39 treated infants).
  • Treatment-related complications were temporary.

Conclusions:

  • Diligent examination for systemic neonatal candidiasis is crucial in high-risk neonates.
  • Combination therapy with amphotericin B and 5-flucytosine is recommended for effective treatment and improved survival rates.