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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Published on: January 29, 2016

Fatigue, depression and progression in multiple sclerosis.

M Koch1, M Uyttenboogaart, A van Harten

  • 1Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands. m.w.koch@neuro.umcg.nl

Multiple Sclerosis (Houndmills, Basingstoke, England)
|June 7, 2008
PubMed
Summary
This summary is machine-generated.

Fatigue and depression in multiple sclerosis (MS) do not predict disease progression. These symptoms tend to persist over time, indicating a stable but chronic experience for many MS patients.

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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
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08:48

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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

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Published on: June 30, 2014

Area of Science:

  • Neurology
  • Clinical Psychology

Background:

  • Fatigue and depression are common symptoms in multiple sclerosis (MS).
  • The long-term impact of these symptoms on MS disease progression and prognosis remains unclear.

Purpose of the Study:

  • To investigate the effect of fatigue and depression on disease progression in MS.
  • To examine the long-term prognosis of fatigue and depression in MS patients.

Main Methods:

  • 228 MS patients assessed for fatigue (Fatigue Severity Scale - FSS) and depression (Center for Epidemiologic Studies Depression Scale - CES-D).
  • Disability scores and secondary progression monitored over 10 years.
  • Repeat assessments of fatigue and depression conducted on a subset of patients after 10 years.

Main Results:

  • Baseline fatigue and depression did not predict secondary progression or disability progression over 10 years.
  • Symptoms of fatigue and depression largely persisted over the 10-year study period.
  • Disability scores significantly increased, while fatigue and depression scores remained relatively stable.

Conclusions:

  • Fatigue and depression in MS appear unrelated to disease progression.
  • These symptoms exhibit chronicity, tending to persist at similar levels over time in MS patients.