Related Experiment Video

Updated: Jul 4, 2026

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model
08:18

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model

Published on: February 8, 2022

Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohort

Jared D Sturgeon1, Aaron R Folsom, W T Longstreth

  • 1Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, 1300 S Second St, Minneapolis, MN 55454-1015, USA.

Stroke
|June 7, 2008
PubMed

Insights

High fibrinogen and von Willebrand factor levels increase intracerebral hemorrhage (ICH) risk. Factor VIII was linked to ICH in younger participants, highlighting novel risk factors for this stroke type.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Hematology

Background:

  • Intracerebral hemorrhagic stroke (ICH) is a severe condition with significant morbidity and mortality.
  • Identifying novel risk factors is crucial for effective prevention strategies.

Purpose of the Study:

  • To identify novel risk factors for intracerebral hemorrhagic stroke (ICH).
  • To investigate the association between specific hemostatic factors and ICH incidence.

Main Methods:

  • Pooled analysis of Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health Study (CHS) cohorts.
  • Involved 21,680 adults aged 45+, with over 263,489 person-years of follow-up.
  • Assessed baseline levels of fibrinogen, von Willebrand factor, Factor VIII, lipoprotein (a), Factor VII, white blood cell count, and C-reactive protein.

Main Results:

  • Each standard deviation increase in fibrinogen was associated with a 35% increased relative rate of ICH.
  • Elevated von Willebrand factor levels (above median) increased ICH likelihood by 1.72 times.
  • Factor VIII showed a positive association with ICH in the ARIC cohort (RR 1.31 per SD) but not in the CHS cohort.
  • No significant association was found between lipoprotein (a), Factor VII, white blood cell count, or C-reactive protein and ICH.

Conclusions:

  • Elevated plasma fibrinogen and von Willebrand factor are associated with increased rates of intracerebral hemorrhage.
  • Factor VIII may contribute to ICH risk, particularly in younger populations as observed in the ARIC study.
  • These findings highlight specific hemostatic markers as potential targets for ICH risk assessment and prevention.
Abstract

More Related Videos

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage09:41

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage

Published on: July 3, 2014

Related Concept Videos

Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...