Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Residents as Teachers in Postgraduate Medical Education: A Structured Review of Global Evidence and Emerging Gaps.

BMC medical education·2026
Same author

Perspectives on Fall Prevention Among Older Patients and Healthcare Providers in UAE Hospitals: A Qualitative Study.

Clinical interventions in aging·2026
Same author

Waist-to-height ratio identifies children with lower physical activity and reduced cardiorespiratory fitness: Longitudinal evidence from Norwegian primary schools - The Health Oriented Pedagogical Project (HOPP).

PloS one·2026
Same author

Circadian clock regulation of hemostasis: a systematic review of molecular pathways.

Research and practice in thrombosis and haemostasis·2026
Same author

Reassessing the role of PPARgamma in vascular effects of cannabinoids: A critical appraisal.

Vascular pharmacology·2026
Same author

Modeling sex-dependent cardiovascular responses to lower body negative pressure.

American journal of physiology. Heart and circulatory physiology·2026

Related Experiment Video

Updated: Jul 4, 2026

Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
10:40

Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model

Published on: August 4, 2012

Reactive hyperemia in the human liver.

Helmut G Hinghofer-Szalkay1, Nandu Goswami, Andreas Rössler

  • 1Institute of Physiology, Center for Physiological Medicine, Medical Univ. Graz, Harrachgasse 21, A-8010 Graz, Austria. helmut.hinghofer@meduni-graz.at

American Journal of Physiology. Gastrointestinal and Liver Physiology
|June 7, 2008
PubMed
Summary

Lower body negative pressure (LBNP) temporarily reduced liver blood flow, but caused reactive hyperemia upon release. This study reveals physiological post-LBNP reactive hyperemia in the human liver.

More Related Videos

Near-Infrared Spectroscopy During Reactive Hyperemia for the Assessment of Lower Limb Vascular Function
04:44

Near-Infrared Spectroscopy During Reactive Hyperemia for the Assessment of Lower Limb Vascular Function

Published on: March 22, 2024

Related Experiment Videos

Last Updated: Jul 4, 2026

Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
10:40

Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model

Published on: August 4, 2012

Near-Infrared Spectroscopy During Reactive Hyperemia for the Assessment of Lower Limb Vascular Function
04:44

Near-Infrared Spectroscopy During Reactive Hyperemia for the Assessment of Lower Limb Vascular Function

Published on: March 22, 2024

Area of Science:

  • Physiology
  • Cardiovascular Science
  • Hepatology

Background:

  • Orthostatic stress simulates standing up, causing central hypovolemia.
  • Understanding liver blood flow regulation during hypovolemia is crucial for physiological responses.

Purpose of the Study:

  • To investigate alterations in hepatic blood flow during and after simulated orthostatic stress using lower body negative pressure (LBNP).
  • To assess the physiological response of the human liver to central hypovolemia.

Main Methods:

  • Lower body negative pressure (LBNP) at 40 mmHg for 15 minutes was applied to induce central hypovolemia.
  • Hemodynamic parameters, plasma density, and indocyanine green (ICG) clearance were measured.
  • Hepatic perfusion was calculated using ICG elimination kinetics.

Main Results:

  • LBNP decreased plasma volume (-10%) and cardiac output (-15%), while increasing heart rate (+14%) and peripheral resistance (+17%).
  • Hepatic perfusion decreased by 22% during LBNP.
  • Immediately after LBNP release, hepatic perfusion increased by 25% above control levels, indicating reactive hyperemia.

Conclusions:

  • Simulated orthostatic stress significantly alters hepatic blood flow, causing a transient decrease followed by reactive hyperemia.
  • The observed post-LBNP hyperemia suggests an autoregulatory vasodilation response to relative hepatic ischemia.
  • This study provides evidence for physiological reactive hyperemia in the human liver following LBNP.