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A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
Published on: July 10, 2017
Stroke among siblings in a biethnic community
Lynda D Lisabeth1, Patricia A Peyser, Jeffrey C Long
1Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA. llisabet@umich.edu
Neuroepidemiology
|June 7, 2008
Summary
Mexican Americans have a higher risk of stroke. Their siblings have double the stroke risk, indicating family history is crucial for identifying at-risk individuals.
Area of Science:
- Neurology
- Genetics
- Public Health
Background:
- Mexican Americans (MAs) exhibit a higher stroke risk than non-Hispanic whites (NHWs), particularly at younger ages.
- Familial aggregation patterns of stroke risk in MAs are not well understood.
- Assessing familial risk may aid in identifying MAs with elevated stroke risk.
Purpose of the Study:
- To estimate the sibling recurrence risk ratio (lambda(s)) for stroke.
- To compare stroke risk among siblings of stroke patients between MAs and NHWs.
Main Methods:
- A population-based study identified 181 stroke and transient ischemic attack (TIA) cases aged 45-64 in a biethnic Texas community.
- Sibling recurrence risk ratio (lambda(s)) was calculated overall and stratified by ethnicity.
Main Results:
- Siblings of ischemic stroke/TIA cases showed a twofold increase in stroke risk (lambda(s) = 1.92).
- The lambda(s) was 2.0 for MA stroke/TIA cases and 1.66 for NHW stroke/TIA cases.
- Elevated sibling recurrence risk was observed in MA stroke/TIA cases.
Conclusions:
- Elevated sibling recurrence risk in MA stroke/TIA cases suggests the need for further ethnic-based genetic studies.
- A positive family history is a valuable clinical tool for identifying MAs at increased stroke risk.
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