[Methods for ensuring the apyrogenic quality of injection solutions in hospital pharmacies]

The existing technology of water production cannot protect injections and solutions from foreign substances. The main ways of the solution contamination are: microbiotic pollution of distilled water, air and manmade pollution. The article deals with a problem of removing pyrogenic substances from parenteral solutions. A special attention is paid to the methods of electrofiltration and ultrafiltration by means of a membrane filter (Soviet production). The authors emphasize the importance of a strict control over pyrogenic tests of injections. The appropriate factory facilities and essential hygienic and sanitary conditions in manufacturing injections will rule out the possibility of its microbiotic pollution.