DNA microarrays in the clinic: infectious diseases

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Vladimir Mikhailovich1, Dmitry Gryadunov, Alexander Kolchinsky

  • 1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|June 7, 2008
PubMed

Insights

Microarray technology shows significant promise for diagnosing and monitoring infectious diseases. This approach aids in identifying various pathogens and analyzing drug resistance patterns for improved public health outcomes.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biotechnology

Background:

  • Infectious diseases remain a critical public health concern, often underestimated in their impact.
  • Advanced diagnostic tools are essential for effective disease management and control.
  • Microarray technology offers a powerful platform for pathogen detection and characterization.

Purpose of the Study:

  • To highlight the potential of microarray technology in clinical diagnostics for infectious diseases.
  • To discuss suitable technologies for pathogen detection and investigation.
  • To illustrate the application of microarrays in identifying various pathogens and their drug resistance.

Main Methods:

  • Review of current microarray technologies applicable to infectious disease diagnostics.
  • Discussion of clinical case studies and applications.
  • Analysis of pathogen detection and drug-resistance profiling using microarrays.

Main Results:

  • Microarrays are increasingly utilized in clinical settings for pathogen identification.
  • The technology enables the detection of diverse pathogens, including mycobacteria, Bacillus anthracis, HIV, and influenza viruses.
  • Microarray analysis facilitates the assessment of drug-resistance patterns in pathogens.

Conclusions:

  • Microarray technology is a highly promising tool for the future of infectious disease diagnostics and monitoring.
  • Its application in identifying pathogens and their resistance profiles can significantly impact public health.
  • Continued development and implementation of microarrays will enhance clinical practice in combating infectious diseases.

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