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Using the E1A Minigene Tool to Study mRNA Splicing Changes
Published on: April 22, 2021
Alternative translation start sites and hidden coding potential of eukaryotic mRNAs
1Institute of Cytology and Genetics, Novosibirsk, Russia. ak@bionet.nsc.ru
Abstract:
It is widely suggested that a eukaryotic mRNA typically contains one translation start site and encodes a single functional protein product. However, according to current points of view on translation initiation mechanisms, eukaryotic ribosomes can recognize several alternative translation start sites and the number of experimentally verified examples of alternative translation is growing rapidly. Also, the frequent occurrence of alternative translation events and their functional significance are supported by the results of computational evaluations. The functional role of alternative translation and its contribution to eukaryotic proteome complexity are discussed.
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