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The promise and perils of 'targeted therapy' of advanced ovarian cancer

Maurie Markman1

  • 1University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. mmarkman@mdanderson.org

Oncology
|June 10, 2008
PubMed

Insights

Targeted therapy for ovarian cancer shows promise, particularly with anti-angiogenic agents. Future research will focus on molecular targets with documented relevance in this malignancy.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Ovarian cancer presents opportunities for targeted therapeutic strategies.
  • Despite extensive research, clinical relevance of many targeted approaches in ovarian cancer remains limited.

Purpose of the Study:

  • To review the current status and future directions of targeted therapy in ovarian cancer.
  • To highlight the potential of anti-angiogenic agents in ovarian cancer treatment.

Main Methods:

  • Review of existing literature on targeted therapies in ovarian cancer.
  • Analysis of the biological activity of anti-angiogenic agents in ovarian cancer models and clinical studies.

Main Results:

  • Anti-angiogenic anti-neoplastic agents demonstrate significant biological activity as single agents in ovarian cancer.
  • Ovarian cancer is a suitable malignancy for exploring targeted therapeutic strategies.

Conclusions:

  • Anti-angiogenic therapy is a clinically relevant targeted approach for ovarian cancer.
  • Future ovarian cancer targeted therapy trials should prioritize molecular targets with established relevance.

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