Related Experiment Video
Updated: Jul 4, 2026
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Retinal function and loss of autofluorescence in stargardt disease
Janet S Sunness1, Joshua N Steiner
1Richard E. Hoover Rehabilitation Services for Low Vision and Blindness, Greater Baltimore Medical Center, Baltimore, MD 21204, USA. jsunness@alum.mit.edu
Objective:
To determine the relationship between reduced retinal autofluorescence and the dense scotomas in Stargardt disease.
Method:
Retrospective review of patients with Stargardt disease seen between 2000 and 2004 at a tertiary referral center.
Patients:
All 32 patients with Stargardt who underwent both autofluorescence (AF) imaging and scotoma mapping were included.
Results:
Forty-seven percent of eyes had dense scotomas corresponding to the areas of loss of AF (27% corresponding to the area of uniform loss of AF, and 20% corresponding to the area of uniform plus mottled loss of AF). Fifty-three percent of eyes did not have a good correlation of the dense scotoma with the area of loss of AF. Both eyes were judged to be in the same group in 75% of patients.
Conclusions:
Areas of reduced AF are measurable, but are not equivalent to the area of dense scotoma in 53% of patients. Measures of retinal sensitivity and scotomas are necessary for defining retinal functional involvement in Stargardt disease.
More Related Videos
08:54A Workflow to Quantitatively Determine Age-Related Macular Degeneration Lesion-Specific Variations in Fundus Autofluorescence
Published on: May 26, 2023
10:39Improved Lipofuscin Models and Quantification of Outer Segment Phagocytosis Capacity in Highly Polarized Human Retinal Pigment Epithelial Cultures
Published on: April 14, 2023
