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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Respiratory viruses in acute respiratory tract infections in Western India

Leena Ravindra Yeolekar1, Rekha Gangadhar Damle, Aarti Nilesh Kamat

  • 1National Institute of Virology, Pune, India.

Indian Journal of Pediatrics
|June 10, 2008
PubMed

Insights

Respiratory syncytial virus (RSV) is the most common cause of acute respiratory tract infections leading to hospitalization in children aged 0-1 year. This study tracked common viral infections in pediatric patients.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Public Health

Background:

  • Acute respiratory tract infections (ARTIs) are a significant cause of morbidity in children.
  • Understanding the epidemiology of respiratory viruses is crucial for effective management and prevention strategies.

Purpose of the Study:

  • To investigate the circulation patterns of respiratory viruses in pediatric patients presenting with ARTIs.
  • To differentiate viral prevalence in outpatient versus hospitalized children.

Main Methods:

  • Nasopharyngeal aspirates were collected from 385 children with ARTIs.
  • Samples were analyzed using immunofluorescence testing (IFT) for seven common respiratory viruses.

Main Results:

  • Overall positivity for respiratory viruses was 37.1%.
  • Respiratory syncytial virus (RSV) was the most prevalent virus (26%), particularly in hospitalized children (39.8%).
  • Influenza viruses were the second most common (5.4%).

Conclusions:

  • RSV is the predominant respiratory viral pathogen necessitating hospitalization in infants (0-1 year).
  • Findings highlight the significant impact of RSV on pediatric hospital admissions.
Abstract

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