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Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
Chronic lung disease in newborns
M Jeeva Sankar1, Ramesh Agarwal, Ashok K Deorari
1Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Insights
Bronchopulmonary dysplasia (BPD), a chronic lung disease in preterm infants, arises from prematurity and respiratory support. Current management strategies offer limited benefits, necessitating evidence-based protocols.
Area of Science:
- Neonatology
- Pediatric Pulmonology
- Developmental Biology
Background:
- Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting preterm infants requiring respiratory support.
- Risk factors include prematurity, oxygen therapy, ventilation, infections, patent ductus arteriosus, and genetic factors.
- Modern BPD presents as a milder form with impaired alveolar development, differing from historical severe inflammatory types.
Purpose of the Study:
- To review and discuss current evidence-based strategies for the prevention and treatment of bronchopulmonary dysplasia.
- To outline a comprehensive management protocol for BPD.
Main Methods:
- Literature review of pharmacological and ventilatory interventions for BPD.
- Synthesis of current evidence to inform management guidelines.
Main Results:
- Many established pharmacological and ventilatory strategies have shown limited efficacy in preventing or treating BPD.
- A shift towards milder forms of BPD characterized by arrested lung development is observed.
Conclusions:
- Effective BPD management requires a comprehensive, evidence-based approach.
- Further research is needed to identify beneficial interventions for BPD.
Abstract:
Chronic lung disease (CLD) or bronchopulmonary dysplasia (BPD) occurs in preterm infants who require respiratory support in the first few days of birth. Apart from prematurity, oxygen therapy and assisted ventilation, factors like intrauterine/postnatal infections, patent ductus arteriosus, and genetic polymorphisms also contribute to its pathogenesis. The severe form of BPD with extensive inflammatory changes is rarely seen nowadays; instead, a milder form characterized by decreased alveolar septation due to arrest in lung development is more common. A multitude of strategies, mainly pharmacological and ventilatory, have been employed for prevention and treatment of BPD. Unfortunately, most of them have not been proved to be beneficial. A comprehensive protocol for management of BPD based on the current evidence is discussed here.
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