Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Alzheimer's Disease: Treatment

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

Dementia

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Selection of monosomic addition plants in offspring families using repetitive DNA probes in Beta L.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013

Same author

Hemato-immunological responses of Heros severus fed diets supplemented with different levels of Dunaliella salina.

Fish physiology and biochemistry·2013

Same author

Improving the health care of geriatric patients: management of urinary incontinence: a position paper.

Zeitschrift fur Gerontologie und Geriatrie·2013

Same author

Boosted selective internal radiation therapy with 90Y-loaded glass microspheres (B-SIRT) for hepatocellular carcinoma patients: a new personalized promising concept.

European journal of nuclear medicine and molecular imaging·2013

Same author

Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2012

Same author

Kalman filter-based time-varying cortical connectivity analysis of newborn EEG.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2012

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

Treatment Target Test Dementia (3TD).

M Mesbah¹, B Grass-Kapanke, R Ihl

¹Department of Psychiatry, University of Duesseldorf, Duesseldorf, Germany. mana.mesbah@alexianer-krefeld.de

International Journal of Geriatric Psychiatry

|June 10, 2008

Summary

A new test, the Training Target Test Dementia (3TD), effectively identifies cognitive and emotional capacity profiles in dementia patients. This tool distinguishes dementia from depression and healthy controls, aiding targeted therapy development.

More Related Videos

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

Related Experiment Videos

Last Updated: Jul 4, 2026

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

Area of Science:

Neuroscience
Psychology
Gerontology

Background:

Goal-oriented therapy for dementia lacks sufficient measurement tools.
Existing tests do not adequately profile patient capacities for targeted training.

Purpose of the Study:

To develop a novel test for profiling capacities in dementia patients.
To create a tool that identifies specific targets for therapeutic interventions in dementia.

Main Methods:

Developed the Training Target Test Dementia (3TD) incorporating intelligence, visuo-spatial, problem-solving, emotional, and executive abilities.
Administered the 3TD to 156 subjects: 30 Alzheimer's dementia patients, 28 with depressive disorder, and 98 healthy controls.
Assessed convergence validity using the Test for the Early Detection of Dementia from depression (TE4D) and Beck Depression Inventory.

Main Results:

The 3TD revealed distinct neuropsychological capacity profiles across the three groups.
Significant differences were observed in all subtests between dementia patients, depressed individuals, and controls.
The 3TD demonstrated high sensitivity and acceptable specificity in differentiating dementia patients from controls, with significant convergence validity (r = 0.77) to the TE4D.

Conclusions:

The identified capacity profiles can guide the development of tailored therapeutic modules for dementia.
The 3TD effectively discriminates between dementia, depression, and healthy aging.
Further research is required to confirm the 3TD's sensitivity for tracking therapeutic improvements.