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Updated: Jul 1, 2026
07:41
A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
Published on: February 20, 2018
Chemokines as pharmacological targets
Emanuela Galliera1, Massimiliano M Corsi, Raffaella Bonecchi
1Laboratory of Leukocyte Biology, Medical Faculty, University of Milan, Milan, Italy.
Mini Reviews in Medicinal Chemistry
|June 10, 2008
Summary
Chemokines are vital for immune cell movement. This review explores chemokine regulation, their role in diseases, and potential as drug targets.
Area of Science:
- Immunology
- Molecular Biology
Background:
- Chemokines are crucial signaling proteins that regulate leukocyte movement.
- Leukocyte recruitment is essential for both normal immune surveillance and inflammatory responses.
Purpose of the Study:
- To review the regulatory mechanisms of the chemokine system.
- To discuss the involvement of chemokines in various human diseases.
- To highlight the potential of chemokines as therapeutic targets.
Main Methods:
- Literature review of scientific publications on chemokines.
- Analysis of the role of chemokines in physiological and pathological conditions.
- Evaluation of current and emerging chemokine-targeting therapies.
Main Results:
- The chemokine system is tightly regulated through various mechanisms.
- Dysregulation of chemokines is implicated in numerous diseases, including autoimmune disorders, cancer, and infections.
- Targeting chemokine pathways offers promising therapeutic strategies.
Conclusions:
- Understanding chemokine regulation is key to modulating immune responses.
- Chemokines represent a significant area for pharmacological intervention in human diseases.
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