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A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion
06:36

A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion

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Suppression of cancer invasiveness by dietary compounds

Daniel Sliva1

  • 1Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA. dsliva@clarian.org

Mini Reviews in Medicinal Chemistry
|June 10, 2008
PubMed

Insights

Dietary compounds like green tea polyphenols can inhibit cancer cell invasion by suppressing key signaling pathways. These natural compounds offer potential as adjuvant therapies to prevent cancer metastasis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Nutritional Science

Background:

  • Tumor invasion and metastasis are critical processes in cancer progression.
  • These processes involve cell growth, adhesion, migration, and tissue degradation, driven by aberrant intracellular signaling.
  • Signaling pathways like AP-1 and NF-kappaB play crucial roles in cancer cell invasiveness.

Purpose of the Study:

  • To review alternative therapeutic strategies for inhibiting cancer cell invasiveness.
  • To highlight the role of dietary compounds in suppressing cancer metastasis.
  • To explore the potential of these compounds in adjuvant or combination cancer therapy.

Main Methods:

  • Literature review of studies on dietary compounds and cancer cell signaling.
  • Analysis of the impact of natural compounds on AP-1 and NF-kappaB pathways.
  • Evaluation of the effects of dietary compounds on cancer cell invasiveness and metastasis.

Main Results:

  • Natural compounds, including green tea polyphenols and soy isoflavones, significantly decrease AP-1 and NF-kappaB signaling.
  • Dietary compounds like mushroom Ganoderma lucidum also suppress these key signaling pathways.
  • These suppressive effects correlate with reduced invasiveness of cancer cells.

Conclusions:

  • Dietary compounds demonstrate potential in inhibiting cancer cell invasion and metastasis.
  • Natural compounds can modulate critical intracellular signaling pathways involved in cancer progression.
  • These findings support the consideration of dietary compounds in adjuvant or combination cancer therapies for metastasis prevention and treatment.

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