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Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging
Published on: April 6, 2014
Pharmacological strategies for neuroprotection in traumatic brain injury
J S Jennings1, A M Gerber, M L Vallano
1Department of Neurosurgery, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA.
Mini Reviews in Medicinal Chemistry
|June 10, 2008
Abstract:
Traumatic brain injury affects over a million Americans annually, but pharmacological therapy remains limited. Current standards of care in acute, subacute and chronic phases of injury are primarily supportive. This review discusses pharmacological strategies and future directions in patient treatment emphasizing pleiotropic agents targeting inflammation, oxidative damage, and glutamate excitotoxicity.
