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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jul 4, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Sclerosing nevus with pseudomelanomatous features.

Giuseppe Fabrizi1, Ilaria Pennacchia, Calogero Pagliarello

  • 1Department of Dermatology, Molise University Medical School, Campobasso, Molise, Italy.

Journal of Cutaneous Pathology
|June 10, 2008
PubMed
Summary

Pigmented lesions with central scarring, despite concerning features, are likely benign melanocytic nevi. These benign nevi exhibit architectural changes and pseudomelanomatous features due to fibrotic processes, not melanoma.

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Area of Science:

  • Dermatopathology
  • Melanocytic Neoplasms
  • Surgical Pathology

Background:

  • Pigmented lesions with central scarring present diagnostic challenges.
  • Some lesions show architectural atypia without cytologic atypia or mitotic activity.
  • The biological nature of these specific lesions requires investigation.

Purpose of the Study:

  • To assess the biological nature of melanocytic neoplasms with central scar-like areas.
  • To differentiate these lesions from malignant melanoma.
  • To understand the role of fibrotic processes in melanocytic lesion morphology.

Main Methods:

  • Selection of 19 melanocytic neoplasms with specific clinical and histological features.
  • Features included central regression, scar-like tissue, atypical nest architecture, and pagetoid spread.
  • Exclusion criteria: cytologic atypia, nodules, mitoses, or necrosis.

Main Results:

  • All 19 cases showed no recurrence or metastasis after follow-up.
  • Histological similarities noted with recurrent nevi and nevi in inflammatory/sclerosing conditions.
  • Pseudomelanomatous features correlated with fibrotic processes, affecting various nevus types.

Conclusions:

  • Lesions with central scarring and pseudomelanomatous features are likely benign melanocytic nevi.
  • Fibrotic processes combined with pseudomelanomatous proliferation characterize these benign lesions.
  • Absence of atypia, mitoses, and nodules differentiates them from regressing melanomas.