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Related Experiment Videos

Retroperitoneal fibrosis.

E S Amis1

  • 1Department of Radiology, Columbia-Presbyterian Medical Center, New York, NY 10032.

AJR. American Journal of Roentgenology
|August 11, 1991
PubMed
Summary
This summary is machine-generated.

Retroperitoneal fibrosis, often idiopathic, involves fibrotic plaques entrapping ureters. Imaging like CT or MR cannot distinguish benign from malignant plaques, requiring histological analysis for diagnosis.

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Area of Science:

  • Medical Imaging
  • Pathology
  • Nephrology

Background:

  • Retroperitoneal fibrosis (RPF) is a condition characterized by a fibrotic plaque in the retroperitoneum.
  • Idiopathic RPF accounts for two-thirds of cases, often presenting as an isolated plaque over the lower lumbar spine entrapping ureters.
  • Potential causes include hypersensitivity reactions to aortic atheromatous plaques, ergot-derivative drugs, hemorrhage, urine extravasation, or desmoplastic responses to tumors.

Purpose of the Study:

  • To describe the characteristics and potential causes of retroperitoneal fibrosis.
  • To highlight the limitations of current imaging techniques in differentiating benign from malignant plaques.
  • To outline the histological progression of the fibrotic plaque.

Main Methods:

  • Review of existing literature on retroperitoneal fibrosis.

Related Experiment Videos

  • Discussion of imaging modalities such as CT and MRI.
  • Histopathological description of early and mature fibrotic plaques.

    • Main Results:

    • Retroperitoneal fibrosis can be idiopathic or secondary to various causes.
    • CT and MR imaging are optimal for visualizing the plaque but cannot differentiate benign from malignant lesions.
    • Early RPF shows inflammation and edema; mature plaques exhibit dense fibrous tissue with minimal cellularity, impacting MR signal characteristics.

    Conclusions:

    • Retroperitoneal fibrosis has diverse etiologies, with idiopathic cases being most common.
    • Accurate differentiation between benign and malignant plaques remains a challenge with current imaging.
    • Histological examination is crucial for understanding the disease progression and its impact on imaging findings.