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Growth patterns in the growth-retarded premature infant
E L Pilling1, C J Elder, A T Gibson
1Jessop Wing, Sheffield Teaching Hospitals NHS Trust, Tree Root Walk, Sheffield S10 2SF, UK.
Summary
Premature infants often experience postnatal growth impairment, impacting final stature. This review examines early growth patterns and their potential long-term health consequences in adulthood.
Area of Science:
- Neonatology
- Pediatric Endocrinology
- Developmental Pediatrics
Background:
- Approximately 10% of infants are born prematurely, with many exhibiting postnatal growth impairment.
- This growth impairment can occur regardless of birth weight for gestational age and is often variable and incomplete, especially in the most immature infants.
- Concerns exist regarding final adult stature and potential links between abnormal early growth and adult disease susceptibility.
Purpose of the Study:
- To review the patterns of postnatal growth in premature infants.
- To assess the potential long-term implications of aberrant early growth on adult health.
- To inform potential therapeutic interventions, such as growth hormone treatment.
Main Methods:
- This is a review article, synthesizing existing literature on infant growth.
- It assesses patterns of postnatal growth and long-term outcomes.
- Evidence regarding growth hormone treatment eligibility is also considered.
Main Results:
- Premature infants frequently display impaired postnatal growth, with catch-up growth being variable and often incomplete.
- Long-term studies indicate potential significant effects on final adult stature.
- Emerging evidence suggests a link between abnormal early growth and increased susceptibility to diseases in adult life.
Conclusions:
- Postnatal growth impairment is a significant concern in premature infants, affecting final stature.
- Early aberrant growth patterns may have profound long-term implications for adult health and disease risk.
- Further research and consideration for interventions like growth hormone therapy are warranted.
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