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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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Published on: March 30, 2018

Xanthogranulomas associated with hematologic malignancy in adulthood.

Brenda A Shoo¹, Kanade Shinkai, Timothy H McCalmont

¹Department of Dermatology, University of California, San Francisco, California, USA. shoob@derm.ucsf.edu.

Journal of the American Academy of Dermatology

|June 10, 2008

Summary

Xanthogranulomatosis (XG) can occur in adults, often without hyperlipidemia, and shares similarities with childhood cases. Adult XG is frequently associated with hematologic disorders, including malignancies.

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Area of Science:

Dermatology
Hematology
Oncology

Background:

Xanthogranulomatosis (XG) is characterized by multiple simultaneous xanthogranulomas.
While initially described in pediatric populations, adult cases of XG are increasingly reported.
Adult XG typically presents without hyperlipidemia, distinguishing it from some other xanthoma types.

Observation:

This report details a 45-year-old male diagnosed with XG and B-cell acute lymphoblastic leukemia.
The case highlights the co-occurrence of XG and hematologic disorders in adults.
A literature review was conducted to explore the association between adult XG and hematologic conditions.

Findings:

Xanthogranulomas in both children and adults exhibit significant clinical and histopathological similarities.
A notable association exists between xanthogranulomas and hematologic malignancies in adult patients.
The simultaneous occurrence of XG and hematologic disorders is a recurring theme in adult cases.

Implications:

The findings suggest a potential link between XG and underlying hematologic malignancies in adults.
Further research is warranted to elucidate the pathogenetic mechanisms connecting XG and hematologic disorders.
Clinicians should consider evaluating for hematologic conditions in adult patients presenting with xanthogranulomas.