Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

In-vitro Mutagenesis

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Generation of biologically responsive colon-like intestinal tissue patches from human induced pluripotent stem cells using a rapid co-differentiation platform.

Stem cell research & therapy·2026

Same author

Membrane transporter progressive ankylosis protein homologue (<i>ANKH</i>/<i>Ank</i>) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation, and ageing.

Frontiers in aging·2025

Same author

Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn's disease.

Journal of cellular and molecular medicine·2024

Same author

Epigenetic and Metabolic Reprogramming of Fibroblasts in Crohn's Disease Strictures Reveals Histone Deacetylases as Therapeutic Targets.

Journal of Crohn's & colitis·2023

Same author

Human Intestinal Dendritic Cells Can Overcome Retinoic Acid Signaling to Generate Proinflammatory CD4 T Cells with Both Gut and Skin Homing Properties.

Journal of immunology (Baltimore, Md. : 1950)·2023

Same author

Buds, clusters, and transitions in 21st century colorectal carcinoma: revolution or reinvention?<sup>†</sup>.

The Journal of pathology·2023

Same journal

Autophagy modulation in ulcerative colitis with traditional Chinese medicine: A review.

Pathology, research and practice·2026

Same journal

Ras signalling in infectious disease pathology: Mechanisms, tissue damage, and clinical implications.

Pathology, research and practice·2026

Same journal

CBFβ-SMMHC in inv(16) AML: Fusion biology, RUNX1 dysregulation, and therapeutic targeting of a leukemogenic protein-protein interaction.

Pathology, research and practice·2026

Same journal

Multifactorial pathophysiology of varicocele: Integrating hemodynamic, oxidative, and endocrine mechanisms.

Pathology, research and practice·2026

Same journal

Comparative pathophysiology and pathology of transient ischemic attack, ischemic stroke, and reperfusion injury: Mechanistic and therapeutic perspectives.

Pathology, research and practice·2026

Same journal

Taraxerol targets the HIF1A-NEK6 axis to block TDE-mediated M2 macrophage polarization and inhibits NSCLC progression.

Pathology, research and practice·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

Apc mice: models, modifiers and mutants.

Amy E McCart¹, Nicola K Vickaryous, Andrew Silver

¹Colorectal Cancer Genetics Group, Institute of Cell and Molecular Science, Barts and The London, Queen Mary's School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, UK.

Pathology, Research and Practice

|June 10, 2008

Summary

This summary is machine-generated.

Apc mutant mouse models are crucial for studying human colorectal cancer and familial adenomatous polyposis. These models help understand genetic influences on disease severity and test new therapies.

More Related Videos

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Real-time Imaging of Myeloid Cells Dynamics in Apc^Min/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Published on: October 6, 2014

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Related Experiment Videos

Last Updated: Jul 4, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Real-time Imaging of Myeloid Cells Dynamics in Apc^Min/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Published on: October 6, 2014

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Area of Science:

Genetics
Oncology
Animal Models

Background:

Adenomatous polyposis coli (APC) gene mutations initiate familial adenomatous polyposis (FAP) and contribute to sporadic colorectal cancer.
The Multiple Intestinal Neoplasia (Min) mouse, with an Apc gene mutation, was the first model for intestinal tumorigenesis and demonstrated genetic modulation of disease severity.
A variety of Apc mutant mouse models have been developed to better represent human polyposis and colon cancer.

Purpose of the Study:

To review Apc mutant mouse models for studying intestinal tumorigenesis.
To discuss the impact of concurrent mutations and genetic background on disease modeling.
To briefly consider the application of these models in drug testing.

Main Methods:

Review of existing literature on Apc mutant mouse models.
Analysis of different Apc mutant mouse strains and their characteristics.
Examination of genetic background effects and compound mutations in disease modeling.

Main Results:

Apc mutant mouse models are valuable in vivo systems for human disease research.
These models have elucidated the role of Apc in intestinal cancer and identified genetic modifiers.
Different Apc mutant models offer varying degrees of accuracy in mimicking human conditions.

Conclusions:

Apc mutant mouse models are essential tools for colorectal cancer and FAP research.
Understanding genetic background and compound mutations is critical for accurate disease modeling.
These models facilitate the investigation of therapeutic strategies for intestinal polyposis and cancer.