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Updated: Jul 4, 2026

Sieving Fruit Pulp to Detect Immature Tephritid Fruit Flies in the Field
Published on: July 28, 2023
Sweet bays of ERAD
Taku Tamura1, James H Cormier, Daniel N Hebert
1Department of Biochemistry and Molecular Biology, University of Massachusetts, 710N. Pleasant Street, Amherst, MA 01003, USA.
Abstract:
Proteins that improperly mature in the endoplasmic reticulum (ER) are dislocated to the cytoplasm for proteasome-mediated destruction. A recent study provides insight into the incompletely understood processes for selection and targeting of aberrant proteins for ER-associated protein degradation. The identification of the ER chaperones GRP94 and BiP as binding partners for the mannose-binding proteins OS-9 and XTP3-B, indicates that these protein complexes bind to aberrant proteins and direct them to the Hrd1 dislocation and ubiquitylation complex in the ER membrane.
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