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Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline
Antony Payton1, Fabio Miyajima, William Ollier
1Centre for Integrated Genomic Medical Research, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK. tony.payton@manchester.ac.uk
Abstract:
NAD(P)H dehydrogenase quinone 2 (NQO2) is a quinone reductase whose functions include the reduction of both oxidative stress during the redox cycle and neurotoxicity caused by the metabolism of catecholamines. We have investigated a functional non-synonymous exon 3 single nucleotide polymorphism (rs1143684) within the NQO2 gene for association with cognitive decline using a cohort of 722 community-dwelling older individuals aged 50 years and over. The volunteers had completed tests that measured fluid intelligence, processing speed, immediate/delayed verbal recall and semantic memory. We observed a nominal significant association between this polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities.
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