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Updated: Jul 4, 2026
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Published on: March 31, 2023
Successful radiofrequency ablation of the cerebral cortex in pigs using the venous system: possible implications for
Benhur D Henz1, Paul A Friedman, Charles J Bruce
1Division of Cardiovascular Disease, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Background:
When pharmacotherapy for epilepsy fails, surgical options, although efficacious, are highly invasive. We explored whether ablation of the cerebral cortex can be performed utilizing the cerebral venous system.
Methods:
Mapping and radiofrequency ablation was performed via the venous system in two pigs.
Results:
Eight targeted sites were successfully accessed and four targeted sites successfully ablated via the central cerebral venous network.
Conclusion:
Electrophysiological mapping and radiofrequency ablation of the cerebral cortex can be performed via the cerebral veins.
