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Updated: Jul 4, 2026

Isolation of Atrial Myocytes from Adult Mice

Isolation of Atrial Myocytes from Adult Mice

Published on: July 25, 2019

Atrial natriuretic peptide stability.

Ronald Zolty¹, Carol Bauer, Pamila Allen

¹Albert Einstein College of Medicine, Division of Cardiology, Bronx, NY 10461, USA. RZOLTY@montefiore.org

Clinical Biochemistry

|June 10, 2008

Summary

Atrial natriuretic peptide (ANP) is stable in blood samples for up to 12 months when stored at -80°C. This finding supports ANP

Area of Science:

Cardiology
Biochemistry

Background:

Atrial natriuretic peptide (ANP) is vital for water balance and a prognostic indicator in chronic heart failure (CHF).
Assessing ANP stability is critical for its reliable use as a cardiac biomarker.

Purpose of the Study:

To evaluate the long-term stability of ANP in blood samples from healthy individuals and CHF patients.
To determine if ANP degrades during storage at -80°C over a 12-month period.

Main Methods:

Blood samples were collected from 10 healthy controls and 12 CHF patients.
Plasma ANP levels were measured using radioimmunoassay at baseline and after 12 months of storage at -80°C.

Main Results:

ANP levels in healthy subjects remained consistent, showing no significant change from baseline (68.5 pg/mL) to 12 months (69.9 pg/mL), p=0.71.

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ANP concentrations in CHF patients also showed no significant degradation, with levels at 12 months (197.8 pg/mL) similar to baseline (199.3 pg/mL), p=0.70.

Conclusions:

Atrial natriuretic peptide (ANP) is a highly stable molecule in plasma.
No evidence of ANP degradation was observed after 12 months of storage at -80°C, validating its use as a stable cardiac biomarker.