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Published on: July 25, 2020
Recombinant human interleukin-2 inhalation powders: preparation and distribution in the alveolus
1School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China. tangyuetian@sina.com
Abstract:
The aim of this work was to prepare recombinant human interleukin-2 (rhIL-2) inhalation powders, and the important parameters such as particle size, the remaining ratio of rhIL-2 were also studied. To elucidate the target effect of rhIL-2 inhalation powders, an in situ pharmacokinetic two-compartment model was used to explain their distribution characteristics in lung epithelial lining fluid and alveolar macrophage in the alveolus after the administration of the rhIL-2 inhalation powders in rats.
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