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Updated: Jul 4, 2026

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
Published on: November 8, 2018
Monoamine metabolism study in severe, early-onset epilepsy in childhood
Bernard Echenne1, Agathe Roubertie, Julie Leydet
1Child Neurology Department, Université de Montpellier, France. b-echenne@chu-montpellier.fr
Purpose:
To investigate the possible dysfunction of monoamine metabolism in patients with early-onset, epileptic encephalopathies.
Methods:
The CSF dopamine, serotonin and biopterin metabolites were studied in 37 patients with severe, mostly drug-resistant epilepsy.
Results:
No significant abnormality was found, whatever the type of epilepsy, cryptogenic or symptomatic.
Conclusions:
The present study failed to demonstrate that dysfunction of the main neurotransmitters pathways is a common phenomenon in children with early-onset, severe epileptic encephalopathy.
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