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Published on: September 20, 2024
Photosensitivity in epileptic syndromes of childhood and adolescence
Yang Lu1, Stephan Waltz, Katja Stenzel
1Neuropaediatric Department of University Hospital of Schleswig-Holstein, Campus Kiel, Germany.
Insights
Children with epilepsy show higher photosensitivity than adults. Idiopathic generalized epilepsy (IGE) had the highest rates, with severe reactions (grades 3-4) most common in IGE patients.
Area of Science:
- Neurology
- Pediatrics
- Epileptology
Background:
- Photosensitivity, a brain reaction to light, is graded 1-4 and common in early life.
- This study focuses on photosensitivity in pediatric epilepsy patients.
Purpose of the Study:
- To investigate the prevalence and characteristics of photosensitivity in children with epilepsy.
- To compare photosensitivity rates between different epilepsy types in pediatric patients.
Main Methods:
- Retrospective analysis of clinical data and EEG records from 566 pediatric epilepsy patients.
- EEG included intermittent photic stimulation using standard techniques.
- Analysis focused on identifying and grading photosensitivity.
Main Results:
- Pediatric patients exhibited higher photosensitivity (46%) than reported adult rates (20%).
- Photosensitivity was more prevalent in idiopathic generalized epilepsy (IGE) (up to 74%) than focal epilepsies (16-23%).
- Severe photoparoxysmal responses (grades 3-4) were significantly more common in IGE (92%) than focal epilepsies.
Conclusions:
- Photosensitivity is present across various pediatric epilepsy types, including IGE, focal epilepsies, and occasional seizures.
- Severe photosensitivity (PPR grades 3-4) is predominantly observed in idiopathic generalized epilepsy.
- A female preponderance in photosensitivity was confirmed in the pediatric cohort.
Purpose:
Photosensitivity, a reaction of the brain to external photic stimulation, can be graded from 1 to 4, and is most frequently seen in the first decades of life. This study investigated photosensitivity in children with epilepsy.
Methods:
A retrospective study performed in the neuropaediatric department of the largest paediatric hospital in Kiel, treating patients at all medical care levels. The clinical data and EEG records of 566 patients with the most common epileptic syndromes were analyzed, in particular regarding photosensitivity. Their EEGs included application of intermittent light stimulation using standard techniques at twice the minimum.
Results:
The proportion of photosensitive patients was significantly higher in the paediatric cohort than in adult patients, as published in the literature: 46% of patients with generalized epilepsies showed photosensitivity as compared to 20% with focal epilepsies. Photosensitivity was more common in idiopathic generalized epilepsy (IGE), (epilepsy with grand mal on awakening, 74%; juvenile absence epilepsy, 56%; juvenile myoclonic epilepsy, 50%; childhood absence epilepsy, 44%) than in focal types (idiopathic partial - Rolandic epilepsy, 23%; symptomatic/cryptogenic type of epilepsy, 16%), while in patients who experienced occasional seizures (neonatal/febrile seizures), this ranged between 40% and 23%, respectively. The generalized photoparoxysmal response, (PPR), grades 3 and 4 were found significantly more often in patients with IGE (92%) than in patients with focal epilepsies. Finally, the female preponderance was confirmed (37% to 27% of all epilepsies).
Conclusions:
Photosensitivity can be detected both in patients with IGE, with idiopathic and symptomatic/cryptogenic types of focal epilepsies, and with epileptic (occasional) seizures. PPR grades 3 and 4 are the most common in IGE.
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