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Evolution of DNA structure: direction, mechanism, rate.

A L Mazin

    Journal of Molecular Evolution
    |October 27, 1976
    PubMed
    Summary

    DNA pyrimidine clustering increases with evolutionary complexity, from invertebrates to mammals. This DNA evolution is linked to mutation accumulation and strand asymmetry, suggesting DNA structure, not protein, is selected.

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    Area of Science:

    • Molecular Biology
    • Evolutionary Biology
    • Genetics

    Background:

    • DNA composition varies across taxa.
    • Pyrimidine clustering is a measurable feature of DNA structure.

    Purpose of the Study:

    • To determine the degree of pyrimidine clustering in DNA across different taxa.
    • To investigate the evolutionary trends and mechanisms of DNA structure modification.

    Main Methods:

    • Analysis of pyrimidine oligonucleotide frequencies in DNA.
    • Correlation analysis between DNA clustering, strand asymmetry, and amino acid substitutions in cytochrome c.

    Main Results:

    • A clear trend of increasing DNA pyrimidine clustering was observed from invertebrates to mammals.
    • Increased DNA clustering correlates positively with purine-pyrimidine imbalance (strand asymmetry).
    • Evolutionary changes in DNA structure, including clustering and asymmetry, appear to be selected.

    Conclusions:

    • DNA evolution may involve selective enrichment of pyrimidines on one strand and purines on the other.
    • The polynucleotide template, rather than the protein product, may be the primary object of selection in DNA evolution.
    • Evolutionary modification of DNA structure might enhance translational interference resistance.

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